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Recent Patents on DNA & Gene Sequences

Editor-in-Chief

ISSN (Print): 1872-2156
ISSN (Online): 2212-3431

Racing of the Biological Pacemaker

Author(s): Han-Gang Yu

Volume 3 , Issue 3 , 2009

Page: [193 - 200] Pages: 8

DOI: 10.2174/187221509789318423

Price: $65

Abstract

Over the past decade, rapid progress in the molecular studies of cardiac ion channels and stem cells biology has led to efforts to create a biological pacemaker to supplement the widely-used electronic pacemaker. This review focuses on the main concepts of cardiac pacemaker activities in different heart regions and the patented approaches to design a working biological pacemaker. The gene-based and cell-based approaches to meet the requirements of a working biological pacemaker are reviewed. Possible future development and precautions for creation of an effective biological pacemaker superior to the electronic counterpart are discussed.

Keywords: Cardiac pacemaker activity, biological pacemaker, HCN pacemaker channels, Kir2.1 potassium channels, inward current, outward current, gene transfer, stem cell, ventricular rate control


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