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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Sleep-Inducing Factors

Author(s): Fabio Garcia-Garcia, Eva Acosta-Pena, Arturo Venebra-Munoz and Eric Murillo-Rodriguez

Volume 8 , Issue 4 , 2009

Page: [235 - 244] Pages: 10

DOI: 10.2174/187152709788921672

Price: $65


Kuniomi Ishimori and Henri Piéron were the first researchers to introduce the concept and experimental evidence for a chemical factor that would presumably accumulate in the brain during waking and eventually induce sleep. This substance was named hypnotoxin. Currently, the variety of substances which have been shown to alter sleep includes peptides, cytokines, neurotransmitters and some substances of lipidic nature, many of which are well known for their involvement in other biological activities. In this chapter, we describe the sleep-inducing properties of the vasoactive intestinal peptide, prolactin, adenosine and anandamide.

Keywords: Humoral sleep regulation, Stress, purine, cannabinoids

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