Abstract
Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz- Jeghers syndrome (PJS).
Keywords: Familial adenomatous polyposis (FAP), Desmoid Tumors, APC mutations, Colorectum, Chemoprevention
Current Molecular Medicine
Title: Gastrointestinal Polyposis Syndromes
Volume: 7 Issue: 1
Author(s): Lodewijk A.A.Brosens, W. Arnout van Hattem, Marnix Jansen, Wendy W.J. de Leng, Francis M. Giardiello and G. Johan A. Offerhaus
Affiliation:
Keywords: Familial adenomatous polyposis (FAP), Desmoid Tumors, APC mutations, Colorectum, Chemoprevention
Abstract: Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz- Jeghers syndrome (PJS).
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Cite this article as:
Lodewijk A.A.Brosens , W. Arnout van Hattem , Jansen Marnix, Wendy W.J. de Leng , Giardiello M. Francis and G. Johan A. Offerhaus , Gastrointestinal Polyposis Syndromes, Current Molecular Medicine 2007; 7 (1) . https://dx.doi.org/10.2174/156652407779940404
DOI https://dx.doi.org/10.2174/156652407779940404 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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