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Current Medicinal Chemistry - Anti-Infective Agents

Editor-in-Chief

ISSN (Print): 1568-0126
ISSN (Online): 1875-600X

Anti-MRSA Cephems: An Update

Author(s): Dane M. Springer

Volume 1 , Issue 3 , 2002

Page: [269 - 279] Pages: 11

DOI: 10.2174/1568012023354929

Price: $65

Abstract

A review of recent developments in the field of anti-MRSA cephems is presented. The R.W. Johnson / Microcide collaboration seems to be the most advanced effort to date, but many other companies are continuing their efforts to develop a cephalosporin for use against serious Gram-positive infections such as MRSA. A detailed account of the progression of the MRSA cephem program at Bristol-Myers Squibb is provided. This work produced a number of compounds that had excellent biological activity, and were safe in a murine model of acute toxicity.

Keywords: anti-mrsa cephem, mrsa cephem


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