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Current Medicinal Chemistry - Anti-Cancer Agents

Editor-in-Chief

ISSN (Print): 1568-0118
ISSN (Online): 1875-5968

Biological Targets of Antitumor Indolocarbazoles Bearing a Sugar Moiety

Author(s): Michelle Prudhomme

Volume 4 , Issue 6 , 2004

Page: [509 - 521] Pages: 13

DOI: 10.2174/1568011043352650

Price: $65

Abstract

Natural and synthetic indolocarbazole compounds have triggered considerable interest since the discovery in 1986 of the inhibitory properties of staurosporine toward protein kinase C (PKC). Later, it has been shown that indolocarbazole compounds may inhibit various kinases, such as cyclin dependent-kinases and / or topoisomerase I, someones behave only as DNA intercalators. In this review are presented various indolocarbazole compounds bearing a sugar moiety and their biological targets. The relevance of these targets to develop indolocarbazole compounds as potential antitumor agents is discussed.

Keywords: indolocarbazoles, protein kinases, topoisomerase I, dna intercalators, antitumor agents


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