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Current Drug Targets - Inflammation & Allergy

Editor-in-Chief

ISSN (Print): 1568-010X
ISSN (Online): 1568-010X

Anti-IgE Therapy in Allergic Asthma

Author(s): Claudia Rolinck-Werninghaus, Ulrich Wahn and Eckard Hamelmann

Volume 4 , Issue 5 , 2005

Page: [551 - 564] Pages: 14

DOI: 10.2174/156801005774322162

Price: $65

Abstract

Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.

Keywords: asthma, atopy, allergic rhinitis, anti-Ige, monoclonal antibody, treatment


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