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Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Editor-in-Chief

ISSN (Print): 1568-0142
ISSN (Online): 1875-6131

All in the Family: The TNF-TNFR Superfamily in the Pathogenesis and Treatment of Rheumatoid Arthritis and other Inflammatory Diseases

Author(s): Nikolay P. Nikolov and Richard M. Siegel

Volume 4 , Issue 6 , 2005

Page: [587 - 596] Pages: 10

DOI: 10.2174/156801405774933133

Price: $65

Abstract

In the last ten years, blockade of the cytokine TNF-alpha has emerged as a powerful new treatment for Rheumatoid Arthritis and related inflammatory disorders. However, differences in efficacy and side effect profiles amongst TNF antagonists have revealed important differences in their mechanisms of action. In addition, TNF is only one of more than nineteen related cytokines in the TNF superfamily, each of which plays a distinct role in immune system homeostasis and function. Blocking agents against other members of the TNF family are in development and hold promise in the treatment of Rheumatoid Arthritis and other autoimmune disorders. Recent progress in the understanding of the biology and effects of antagonizing therapeutically relevant TNF family members will be reviewed.

Keywords: lymphotoxin (LT), peptide-analog antagonists, gene knockout mice, anti-tumor necrosis factor, B lymphocyte stimulator, OX40 receptor-ligand


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