Abstract
The learning and memory deficits have been recognized as severe and consistent neurological disorders associated with numerous neurodegenerative states. Research in this area has gained momentum only in the recent past after the biochemical and physiological basis of these processes have been understood. A considerable alteration in the neurotransmission is a consistent finding in cognitive disorders. Therefore, many therapeutic strategies to augment the concentration of neurotransmitters in brain such as cholinergic agents, biogenic amines and neuropeptides etc. have been evaluated in cognitive deficits. CNS modulators are the type of antiamnesics that act via modulation of the neurological processes underlying memory storage. These include psychostimulants, excitatory amino acids and most important of all “nootropics”. Nootropics are a heterogeneous group of compounds of diverse chemical composition and biological function that allegedly facilitate learning and memory or overcome natural or induced cognitive impairments. The literature survey incorporated in this article hallmarks the success achieved in the design and development of potential nootropic agents. Additionally, this review is an attempt towards discussing various approaches available to enhance memory, along with the classification of the known memory enhancers, authors research work towards various structural modifications carried out and the biological screening.
Keywords: Nootropics, Neurotransmission substitution therapies, CNS modulators, Metabolic enhancers, Cholinergic activators, racetams, Paracetamol derivatives, Antiamnesic activity
Current Medicinal Chemistry
Title: Towards Better Brain Management: Nootropics
Volume: 14 Issue: 2
Author(s): Ruchi Malik, Abhijeet Sangwan, Ruchika Saihgal, Dharam Paul Jindal and Poonam Piplani
Affiliation:
Keywords: Nootropics, Neurotransmission substitution therapies, CNS modulators, Metabolic enhancers, Cholinergic activators, racetams, Paracetamol derivatives, Antiamnesic activity
Abstract: The learning and memory deficits have been recognized as severe and consistent neurological disorders associated with numerous neurodegenerative states. Research in this area has gained momentum only in the recent past after the biochemical and physiological basis of these processes have been understood. A considerable alteration in the neurotransmission is a consistent finding in cognitive disorders. Therefore, many therapeutic strategies to augment the concentration of neurotransmitters in brain such as cholinergic agents, biogenic amines and neuropeptides etc. have been evaluated in cognitive deficits. CNS modulators are the type of antiamnesics that act via modulation of the neurological processes underlying memory storage. These include psychostimulants, excitatory amino acids and most important of all “nootropics”. Nootropics are a heterogeneous group of compounds of diverse chemical composition and biological function that allegedly facilitate learning and memory or overcome natural or induced cognitive impairments. The literature survey incorporated in this article hallmarks the success achieved in the design and development of potential nootropic agents. Additionally, this review is an attempt towards discussing various approaches available to enhance memory, along with the classification of the known memory enhancers, authors research work towards various structural modifications carried out and the biological screening.
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Cite this article as:
Malik Ruchi, Sangwan Abhijeet, Saihgal Ruchika, Paul Jindal Dharam and Piplani Poonam, Towards Better Brain Management: Nootropics, Current Medicinal Chemistry 2007; 14 (2) . https://dx.doi.org/10.2174/092986707779313408
DOI https://dx.doi.org/10.2174/092986707779313408 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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