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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A One Pot Green Synthesis of 3,4 Dihydropyrimidin-2-(1H)-ones/Thiones Catalyzed By MgO-ZrO2 Under Solvent-Free Conditions

Author(s): Manoj B. Gawande, Deepak M. Nagrik and Damodar M. Ambhore

Volume 9 , Issue 1 , 2012

Page: [12 - 18] Pages: 7

DOI: 10.2174/157017812799303980

Price: $65

Abstract

An efficient green synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones (DHPMs) using MgO/ZrO2 as heterogeneous basic catalyst from an aldehyde, β-keto ester and urea/thiourea under solvent-free conditions is described. A variety of aldehydes were studied with β-keto ester and urea/thiourea giving good to excellent yield of corresponding 3,4-dihydropyrimidin-2-(1H)-ones/thiones. This protocol has advantage of excellent yield, reusability, inexpensive and short reaction time at room temperature. The synthesized catalyst can be reused up to 5 consecutive cycles without any decrease in the yield.

Keywords: DHPMs, green synthesis, multicomponent reactions (MCRs), MgO-ZrO2, medicinal chemistry, alkaloids, Biginelli dihydropyrimidinones, Hantzsh type, batzelladine, anticancer drugs


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