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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

Author(s): Z.-J. Huang, Y. Zeng, P. Lan, P.-H. Sun and W.-M. Chen

Volume 11 , Issue 13 , 2011

Page: [1122 - 1129] Pages: 8

DOI: 10.2174/138955711797655362

Price: $65


Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

Keywords: Berberine, structural modification, biological activities, isoquinoline alkaloid, Chinese herbs, Coptidis Rhizome, antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, antimalaria

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