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Current Immunology Reviews (Discontinued)

Editor-in-Chief

ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Anti-Tumor Necrosis Factor Blocking Agents in the Treatment of Systemic Vasculitis

Author(s): Marzouq Qubti and Philip Seo

Volume 7 , Issue 4 , 2011

Page: [423 - 428] Pages: 6

DOI: 10.2174/157339511797535144

Price: $65

Abstract

The primary systemic vasculitides are idiopathic disorders characterized by the inflammatory destruction of blood vessel walls. Many of these disorders are treated with high-dose glucocorticoids and cytotoxic agents which, while effective, are associated with substantial morbidity, particularly for patients who experience recurrent flares requiring chronic therapy. Therefore, attention has turned towards biologic therapies that abrogate specific elements in the inflammatory cascade. Tumor necrosis factor-α is a cytokine that is central to systemic inflammation in many diseases. This article will review the role played by tumor necrosis factor-α in the pathogenesis of systemic vasculitis, and attempt to define a role for blockade of tumor necrosis factor-α in the treatment of patients with these diseases.

Keywords: Vasculitis, tumor necrosis factor, giant cell arteritis, ANCA-associated vasculitis, systemic vasculitis, biologic therapies, inflammation, tumor necrosis factor-a, interleukin-1, Takayasu's arteritis


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