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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Vinylphosphonates and its First Exploration of Bioactivity

Author(s): Sheng-Nan Li, Lan-Ting Xu, Yue Chen, Ju-Lian Li and Ling He

Volume 8 , Issue 6 , 2011

Page: [416 - 422] Pages: 7

DOI: 10.2174/157017811796064467

Price: $65

Abstract

Phosphonation of β-nitro-alkene with triethyl phosphite was achieved under microwave irradiation using CH2Cl2 as the solvent in the absence of catalyst with moderate to high yields (up to 90%). This method of formation of carbonphosphor bonds is simple, mild, convenient and effective. Synchronously, a number of vinylphosphonates derivatives were synthesized and evaluated biologically preliminary.

Keywords: Vinylphosphonate, phosphonation, triethyl phosphite, B-nitro-alkene, microwave irradiation, carbonphosphor, enantioselective, Phosphorus-alkene bonds, organophosphorus, Horner-Wadsworth-Emmons reaction


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