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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and DPPH Radical Scavenging Activity of 5-Arylidene-N,Ndimethylbarbiturates

Author(s): Khalid Mohammed Khan, Momin Khan, Muhammad Ali, Muhammad Taha, Abdul Hameed, Sajjad Ali, Shahnaz Perveen and M. Iqbal Choudhary

Volume 7 , Issue 3 , 2011

Page: [231 - 236] Pages: 6

DOI: 10.2174/157340611795564231

Price: $65

Abstract

Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.

Keywords: DPPH Radical scavengers, N,N-dimethylbarbiturates, N,N-dimethylbarbituric acid, DPPH, scavenging activity, antioxidant, spectroscopic techniques, elemental analysis, Barbituric acid, n-propyl gallate


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