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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer

Author(s): Vinaykumar S. Velingkar and Vikrant D. Dandekar

Volume 8 , Issue 3 , 2011

Page: [268 - 275] Pages: 8

DOI: 10.2174/157018011794578169

Price: $65

Abstract

A novel class of compounds with structure Aryl propyl acridone-4-carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.

Keywords: Aryl propyl acridone-4-carboxamides, Microwave, Chemosensitizing agents


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