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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

Author(s): Tatjana G. Tolstikov, Mikhail V. Khvostov, Galina I. Lifshits, Alexander V. Dushkin and Elezaveta S. Meteleva

Volume 8 , Issue 3 , 2011

Page: [201 - 204] Pages: 4

DOI: 10.2174/157018011794578222

Price: $65

Abstract

The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacons anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).

Keywords: Arabinogalactan, Clathration, Glycyrrhizic acid, Warfarin


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