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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Esters of Dehydroepiandrosterone (DHEA) as Probes for the Active Site of Type 3 17β-Hydroxysteroid Dehydrogenase (17β-HSD3)

Author(s): Moniola S. Olusanjo, Caroline P. Owen and Sabbir Ahmed

Volume 7 , Issue 5 , 2010

Page: [365 - 369] Pages: 5

DOI: 10.2174/157018010791163505

Price: $65

Abstract

We report the use of steroid-based compounds as probes for the active site of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds were good inhibitors of 17β-HSD3 – a number were extremely potent with respect to the standard compounds used.

Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound


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