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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimers Disease Signaling Cascade

Author(s): Balladka Kunhanna Sarojini, Marakkur Vidyagayatri, Chenna Govindaraju Darshanraj, Basavapattana Rudresh Bharath and Hanumanthappa Manjunatha

Volume 7 , Issue 3 , 2010

Page: [214 - 224] Pages: 11

DOI: 10.2174/157018010790596588

Price: $65

Abstract

A series of new 1,3-disubstituted-1H-pyrazol-5-ols (3) which are the analogues of known radical scavenger ‘edaravone’ are synthesized, characterized and evaluated for DPPH scavenging capacity. The docking studies are carried out for these compounds in the enol form and also in the respective keto form against the proteins and peptides involved in Alzhemier disease signal cascade. Some of them showed good radical scavenging capacity and molecular binding.

Keywords: AD, Pyrazole derivative, DPPH assay, Molecular docking studies, GSK-3β, β-secretase


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