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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Hologram QSAR Studies of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides Derivatives as Selective Peripheral Benzodiazepine Receptor Ligands

Author(s): M. Ye

Volume 7 , Issue 2 , 2010

Page: [133 - 138] Pages: 6

DOI: 10.2174/157018010790225886

Price: $65

Abstract

Peripheral benzodiazepine receptor (PBR) is an important target for the development of drugs to treat anxiety and sleep disorders. Hologram QSAR models were built for good statistical results. Contribution map analysis explains the individual atomic contributions to the overall activity. This HQSAR model should be useful for the further development of novel structurally related PBR ligands.

Keywords: Peripheral benzodiazepine receptor, Hologram QSAR


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