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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Topical DNA Vaccination with DNA/Lipid Based Complex

Author(s): Myeong J. Choi, Jong H. Kim and Howard I. Maibach

Volume 3 , Issue 1 , 2006

Page: [37 - 45] Pages: 9

DOI: 10.2174/156720106775197484

Price: $65

Abstract

Topical DNA vaccines have been shown to elicit both broad humoral and cellular immune response in vivo. The skin is an attractive site for the delivery DNA antigens for DNA vaccination. However, due to skins barrier properties, the penetration of DNA and the applications of topical vaccination are limited. To improve permeability of stratum corneum and the potency of topical DNA vaccines, efficient delivery systems are needed. Topical vaccination has been achieved using topical application of naked DNA with or without tape stripping and DNA/lipid based complex such as liposomes, niosomes, Transfersomes®, or microemulsion. All methods resulted in significant enhancement in humoral and cellular immune response over naked DNA alone. To develop more cost-effective and needle free vaccines, skin targeted immunizations are required. This overview focuses on the comparison of the potency of topical DNA vaccine between naked DNA and DNA-lipid based complex.

Keywords: Topical DNA vaccine, naked DNA, DNA-lipid complex, liposomes, cationic nanoparticles, microemulsion


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