Abstract
The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.
Keywords: Filoviridae, Ebola virus, Marburg virus, drug targets, therapeutics, pathogenesis, pathology, immunotherapy
Infectious Disorders - Drug Targets
Title: Drug Targets in Infections with Ebola and Marburg Viruses
Volume: 9 Issue: 2
Author(s): Olinger G. Gene, Biggins E. Julia, Melanson R. Vanessa, Wahl-Jensen Victoria, Geisbert W. Thomas and Hensley E. Lisa
Affiliation:
Keywords: Filoviridae, Ebola virus, Marburg virus, drug targets, therapeutics, pathogenesis, pathology, immunotherapy
Abstract: The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.
Export Options
About this article
Cite this article as:
Gene G. Olinger, Julia E. Biggins, Vanessa R. Melanson, Victoria Wahl-Jensen, Thomas W. Geisbert and Lisa E. Hensley, Drug Targets in Infections with Ebola and Marburg Viruses, Infectious Disorders - Drug Targets 2009; 9 (2) . https://dx.doi.org/10.2174/187152609787847730
DOI https://dx.doi.org/10.2174/187152609787847730 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current Prospective of Aldose Reductase Inhibition in the Therapy of Allergic Airway Inflammation in Asthma
Current Molecular Medicine Basilar Apex Aneurysms in the Setting of Carotid Artery Stenosis: Case Series and Angiographic Anatomic Study
Current Neurovascular Research Treatment of Viral Encephalitis
Central Nervous System Agents in Medicinal Chemistry Therapeutic Strategies Targeting Endothelial Function in Humans:Clinical Implications
Current Vascular Pharmacology Nature and Nurture in the Early-Life Origins of Metabolic Syndrome
Current Pharmaceutical Biotechnology Gender Specific Aspects of Cell Death in the Cardiovascular System
Current Pharmaceutical Design Current Research on Opioid Receptor Function
Current Drug Targets Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders
Current Pharmaceutical Design Anti-Tumor Necrosis Factor Blocking Agents in the Treatment of Systemic Vasculitis
Current Immunology Reviews (Discontinued) Potential Cardio-Protective Agents: A Resveratrol Review (2000-2019)
Current Pharmaceutical Design Renal Artery Stenting: Efficacy and Complications
Current Hypertension Reviews Genistein: A Phytoestrogen with Multifaceted Therapeutic Properties
Mini-Reviews in Medicinal Chemistry Modulation of Ion Channels in Pulmonary Arterial Hypertension
Current Pharmaceutical Design Tyrosine Kinases and Inflammatory Signalling
Current Molecular Medicine Deciphering the Antibodyome - Peptide Arrays for Serum Antibody Biomarker Diagnostics
Current Proteomics Deciphering Supportive Treatment Strategies for Toxic Epidermal Necrolysis
Current Drug Safety Current Treatment of HIV Infection
Current Topics in Medicinal Chemistry Hypertension and Diabetes: Emphasis on the Renin-Angiotensin System in Atherosclerosis
Current Hypertension Reviews Cyclosporin A: A Therapeutic Strategy in Allergic Diseases
Letters in Drug Design & Discovery Drug Targeting of Estrogen Receptor Signaling in the Cardiovascular System: Preclinical and Clinical Studies
Current Medicinal Chemistry - Cardiovascular & Hematological Agents