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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Depsipeptides from Microorganisms: A New Class of Antimalarials

Author(s): Jean Fotie and Rachel E. Morgan

Volume 8 , Issue 11 , 2008

Page: [1088 - 1094] Pages: 7

DOI: 10.2174/138955708785909916

Price: $65


Depsipeptides are a large group of natural products produced by fungi, actinomycetes, cyanobacteria, higher plants and marine organisms. This family of compounds is known to exhibit a wide range of biological activities, and thanks to the progress of isolation techniques and the advances of methods for structure determination, the numbers of depsipeptides having both unique structures and attractive biological activities are increasing. Many of these compounds have shown a wide range of biological activities, and some are in clinical use or have entered human clinical trials as antibiotic or anticancer agents. However, only a handful of them have been evaluated for their antimalarial activity. This paper aims to review the recent advances in depsipeptides as potential antimalarial compounds.

Keywords: Depsipeptides, Microorganisms, Antimalarials, actinomycetes, cyanobacteria, marine organisms, biological activities, isolation techniques, anticancer agents

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