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Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Knock-Out Mice in Osteoarthritis Research

Author(s): Aurelia Raducanu and Attila Aszodi

Volume 4 , Issue 3 , 2008

Page: [183 - 192] Pages: 10

DOI: 10.2174/157339708785133578

Price: $65

Abstract

Osteoarthritis (OA) is the most common degenerative disorder of the joints with an etiology involving genetic and environmental factors. Although various animal models have been used to elucidate the pathogenesis of OA, in the past decade gene targeting in mice has become one of the most powerful tools to dissect the molecular mechanisms of the disease. The generation of knockout mice has enormously accelerated the identification of the key genetic players in articular cartilage homeostasis and made a significant contribution to further our understanding of OA pathology. In this review, we will outline the phenotypes of the currently available mouse strains, carrying either engineered or spontaneous gene mutations, which provide insight into the processes of articular cartilage destruction. The analysis of these mice reveals a complex interaction among cytokines, proteases, transcription factors, extracellular matrix, cell surface and signaling molecules during the initiation and progression of OA and, in some cases, suggests new therapeutic interventions for the disease.

Keywords: Osteoarthritis, gene targeting, mouse models, extracellular matrix, signaling, proteolysis, cytokines, growth factors


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