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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs)

Author(s): Andrew R. Hudson, Steven L. Roach and Robert I. Higuchi

Volume 8 , Issue 9 , 2008

Page: [750 - 765] Pages: 16

DOI: 10.2174/156802608784535048

Price: $65

Abstract

Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.

Keywords: SGRM, glucocorticoid, nonsteroidal, modulator, transactivation, transrepression, dissociated, inflammation, multiple myeloma


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