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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Schiff Bases of Istain: Potential Anti-Leishmanial Agents

Author(s): Khalid Mohammed Khan, Uzma Rasool Mughal, Samreen, Shahnaz Perveen and Muhammad Iqbal Choudhary

Volume 5 , Issue 4 , 2008

Page: [243 - 249] Pages: 7

DOI: 10.2174/157018008784619915

Price: $65

Abstract

A series of Schiff bases 1-20 was synthesised by the condensation of isatin with primary aromatic amines. All the synthesized compounds 1-20 were randomly screened for their in vitro anti-leishmanial potential. Compounds 2, 5, 7, 10, 13 and 16 also showed good anti-leishmanial activities having IC50 value 4.77 ± 0.1, 6.85 ± 0.21, 1.84 ± 0.2, 2.44 ± 0.03, 4.70 ± 0.04 and 8.58 ± 0.04 μg/mL, respectively. Remaining compounds with IC50 values grater than 10.00 μg/mL were considered to be inactive. Their activity was compared with standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.1 μg/mL). The structures of all the synthesised compounds were deduced by spectroscopic analysis.


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