Abstract
We report the results of the biochemical evaluation of a series of imidazole-based compounds against the hydroxysteroid dehydrogenase (HSD) family of enzymes, in particular, types 1 and 3 of 17β-HSD and 3β-HSD. The results show that the synthesised compounds were good inhibitors of this family of enzymes.
Keywords: Enzyme, Inhibition, Azole, Hydroxysteroid dehydrogenase, 17α-hydroxylase, 17,20-lyase
Letters in Drug Design & Discovery
Title: Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds
Volume: 5 Issue: 1
Author(s): Sabbir Ahmed, Moniola S. Olusanjo, Imran Shahid and Caroline P. Owen
Affiliation:
Keywords: Enzyme, Inhibition, Azole, Hydroxysteroid dehydrogenase, 17α-hydroxylase, 17,20-lyase
Abstract: We report the results of the biochemical evaluation of a series of imidazole-based compounds against the hydroxysteroid dehydrogenase (HSD) family of enzymes, in particular, types 1 and 3 of 17β-HSD and 3β-HSD. The results show that the synthesised compounds were good inhibitors of this family of enzymes.
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Cite this article as:
Ahmed Sabbir, Olusanjo S. Moniola, Shahid Imran and Owen P. Caroline, Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds, Letters in Drug Design & Discovery 2008; 5 (1) . https://dx.doi.org/10.2174/157018008783406705
DOI https://dx.doi.org/10.2174/157018008783406705 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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