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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors

Author(s): Todd A. Houston and Joanne T. Blanchfield

Volume 3 , Issue 7 , 2003

Page: [669 - 678] Pages: 10

DOI: 10.2174/1389557033487827

Price: $65

Abstract

Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.

Keywords: glycosidase inhibitors, glucosidase, mannosidase, galactosidase, sialidase, salacinol, cyclophellitol


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