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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Prevention of Cell Damage in Ischaemic-Reperfusion: Mitochondrial Respiratory Chain as a Pharmacological Target

Author(s): D. Morin, R. Zini, J. P. Tillement and A. Berdeaux

Volume 1 , Issue 3 , 2004

Page: [279 - 284] Pages: 6

DOI: 10.2174/1570180043398803

Price: $65

Abstract

Ischaemic diseases, a major public health problem worldwide, are associated with a decrease in oxygen supply to mitochondria that impairs respiration, energy production and constitute stimuli for cell death. This paper summarises the pharmacological strategies targeting the mitochondrial respiratory chain, which represents an interesting therapeutic perspective.

Keywords: Ischaemia, reperfusion, mitochondrion, respiratory chain, atp, anti-ischaemic drugs


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