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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Role of 1,4-Benzothiazine Derivatives in Medicinal Chemistry

Author(s): R. Fringuelli, L. Milanese and F. Schiaffella

Volume 5 , Issue 12 , 2005

Page: [1061 - 1073] Pages: 13

DOI: 10.2174/138955705774933365

Price: $65


1,4-Benzothiazine (1,4-BT) derivatives have been reported to exhibit a wide range of pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-rheumatic, anti-allergic, vasorelaxant, anti-arrhythmic, anti-hypertensive, neuroprotective and cytotoxic activities. These different effects indicate that 1,4-BT is a template potentially useful in medicinal chemistry research and therapeutic applications.

Keywords: Candida infections, Rheumatoid arthritis, ALDOSE-REDUCTASE INHIBITORS, benzothiazepine nucleus, nimodipine, NEUROPROTECTIVE, anti-tumor

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