Role of 2-Antiplasmin in Cardiovascular System

Title: Role of 2-Antiplasmin in Cardiovascular System

Volume: 2 Issue: 3

Author(s): En Shu, Hiroyuki Matsuno, Yasuo Kitajima and Osamu Kozawa

Affiliation:

Keywords: antiplasmin, myocardial infarction, re-endothelialization, vegf, vegfr-1

Abstract: Inhibition of the blood fibrinolytic system (plasminogen/plasmin) occurs either at the level of plasminogen activators, regulated by specific plasminogen activator inhibitors (PAIs) or at the level of plasmin, mainly regulated by α2-antiplasmin (α2-AP). In this contribution, we focused on the roles of α2-AP in acute myocardial infarction and vascular remodeling associated with cardiovascular diseases. Our findings have identified a new target for the development of new therapeutics for the clinical therapy of cardiovascular diseases.

Cite this article as:

Shu En, Matsuno Hiroyuki, Kitajima Yasuo and Kozawa Osamu, Role of 2-Antiplasmin in Cardiovascular System, Letters in Drug Design & Discovery 2005; 2 (3) . https://dx.doi.org/10.2174/1570180053765129