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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Role of 2-Antiplasmin in Cardiovascular System

Author(s): En Shu, Hiroyuki Matsuno, Yasuo Kitajima and Osamu Kozawa

Volume 2 , Issue 3 , 2005

Page: [172 - 176] Pages: 5

DOI: 10.2174/1570180053765129

Price: $65


Inhibition of the blood fibrinolytic system (plasminogen/plasmin) occurs either at the level of plasminogen activators, regulated by specific plasminogen activator inhibitors (PAIs) or at the level of plasmin, mainly regulated by α2-antiplasmin (α2-AP). In this contribution, we focused on the roles of α2-AP in acute myocardial infarction and vascular remodeling associated with cardiovascular diseases. Our findings have identified a new target for the development of new therapeutics for the clinical therapy of cardiovascular diseases.

Keywords: antiplasmin, myocardial infarction, re-endothelialization, vegf, vegfr-1

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