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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 2 (mGluR2)

Author(s): Michael T. Rudd and John A. McCauley

Volume 5 , Issue 9 , 2005

Page: [869 - 884] Pages: 16

DOI: 10.2174/1568026054750281

Price: $65


This article describes recent medicinal chemistry progress toward selective potentiators of the metabotropic glutamate receptor 2 (mGluR2). Groups at Lilly and Merck have identified new classes of potentiators that exhibit selectivity for mGluR2 over the seven other subtypes of mGluRs. Structure-activity relationships as well as pharmacokinetic properties and in vivo activity are reviewed.

Keywords: glutamate, mglur, group II, potentiator, agonist

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