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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Hypothesis of the Catalytic Action of Nucleic Acid on the Conversion of Prion Protein

Author(s): Yraima Cordeiro and Jerson L. Silva

Volume 12 , Issue 3 , 2005

Page: [251 - 255] Pages: 5

DOI: 10.2174/0929866053587138

Price: $65

Abstract

The main hypothesis for prion diseases proposes that the cellular protein (PrPC) can be altered into a misfolded, β-sheet-rich isoform (PrPSc). We describe here that host nucleic acid may catalyze the conversion between PrPC and PrPSc isoforms, by reducing the protein mobility and by making the protein-protein interactions more likely. We summarize the findings, focusing in the biological relevance of the catalytic action of nucleic acid.

Keywords: prion, structural conversion, nucleic acid, catalysis, aggregation


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