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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Using 5-Hydroxytryptophan as a Probe to Follow Protein-Protein Interactions and Protein Folding Transitions

Author(s): Fernando Correa and Chuck S. Farah

Volume 12 , Issue 3 , 2005

Page: [241 - 244] Pages: 4

DOI: 10.2174/0929866053587057

Price: $65


5-Hydroxytyptophan is a fluorescent tryptophan analog that can be incorporated into recombinant proteins expressed in E. coli and is particularly useful in studies of biological systems that involve supermolecular aggregates of more than one protein. Here we review the varied applications of 5-hydroxytryptophan to study structure, interactions, conformational change and dynamics in complex protein systems.

Keywords: 5-hydroxytryptophan, tryptophan, fluorescence, protein structure, protein-protein interactions, protein folding

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