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Vascular Disease Prevention (Discontinued)


ISSN (Print): 1567-2700
ISSN (Online): 1567-2700

Myocardial Cellular Damage and Antioxidant Status in Off-Pump Versus On-Pump Coronary Artery Bypass Grafting - A Prospective Study

Author(s): Santosh Shinde, Kumud Golam, Pawan Kumar and Neela Patil

Volume 2 , Issue 4 , 2005

Page: [267 - 271] Pages: 5

DOI: 10.2174/1567270010502040267

Price: $65


Coronary artery bypass grafting (CABG) is usually performed with cardiopulmonary bypass (CPB). The offpump CABG technique is an alternative to the standard on-pump technique. The purpose of this study was to evaluate myocardial cell damage and antioxidant status in off-pump and on-pump CABG. Patients (30 men and 15 women) undergoing CABG were included. The off-pump technique was used in 25 patients (mean age 59 ± 10 years). The on-pump technique was used in 20 patients (mean age of 57 ± 11 years). Tissue injury markers [e.g. creatine kinase (CK), CK-MB isoenzyme and cardiac troponin-I (cTnI)] and antioxidant markers [e.g. glutathione peroxidase (GPx), superoxide dismutase (SOD) and malondialdehyde (MDA)] were measured before and 1, 6, 24, 48 and 72h postoperatively. The levels of CK, CK-MB after the on-pump technique were significantly higher when compared to after off-pump CABG (p < 0.001). cTnI levels followed the same pattern (p < 0.001). MDA levels after on-pump CABG were higher than after off-pump CABG (p < 0.001). These findings suggest that off-pump CABG causes less myocardial injury than the on-pump technique.

Keywords: off-pump cabg, on-pump cabg, cardiac enzymes, cardiac troponin I, antioxidants

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