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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Peroxisome Proliferator-Activated Receptor Agonists as Potential Therapeutic Agents in Multiple Sclerosis

Author(s): Masaaki Niino

Volume 7 , Issue 11 , 2007

Page: [1129 - 1135] Pages: 7

DOI: 10.2174/138955707782331687

Price: $65

Abstract

Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for gene regulation in glucose and lipid metabolism. It has been recently implicated that PPARs regulate cellular proliferation and inflammatory responses; some agonists for PPARs ameliorate experimental autoimmune encephalomyelitis, a model of multiple sclerosis (MS) in humans. This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS.

Keywords: PPAR, multiple sclerosis, experimental autoimmune encephalomyelitis, cytokine, inflammation


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