Generic placeholder image

Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales

Author(s): Kenneth L. Kirk

Volume 6 , Issue 14 , 2006

Page: [1447 - 1456] Pages: 10

DOI: 10.2174/156802606777951073

Price: $65


Several strategies used in the rational design and synthesis of fluorinated compounds as potential therapeutic agents are reviewed. Applications of fluorine substitution in empirical SAR studies for lead development also are discussed, along with the implications with respect to fluorine target interactions that can be derived from biological activities.

Keywords: fluorine substitution, 5-Fluorouracil (5-FU), T138067, Hydrolytic stability, cholesterol acyl transferas, monofluorination

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy