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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives

Author(s): Alma D. Miranda-Olvera, Ignacio A. Rivero Espejel and Luis M. De Leon Rodriguez

Volume 4 , Issue 4 , 2007

Page: [261 - 264] Pages: 4

DOI: 10.2174/157017807781024246

Price: $65


Currently, the generation of peptide ligand libraries where ligand position and identity are varied leading to the discovery of optimal peptide activity and stability is limited. Thus, in this work the synthesis of a p-Dde-Nα-Fmocphenylalanine residue is reported followed by its application in the microwave assisted synthesis of labeled HYNIC Phe8- oxitocine derivatives.

Keywords: Microwave, oxytocin, HYNIC, peptide, libraries, conjugate

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