Generic placeholder image

Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Neurotrophic Effects of the Peptide NAP: A Novel Neuroprotective Drug Candidate

Author(s): Illana Gozes and Irit Spivak-Pohis

Volume 3 , Issue 3 , 2006

Page: [197 - 199] Pages: 3

DOI: 10.2174/156720506777632790

Price: $65

Abstract

This short review outlines the scientific progression from the neuropeptide vasoactive intestinal peptide as a neuroprotective agent that acts through glial cells to increase and modulate the synthesis and secretion of novel neuroprotective substances. Recent development in the studies on activity-dependent neuroprotective protein (ADNP) and activitydependent neurotrophic factor (ADNF) and short peptide derivatives of these proteins, ADNF-9 and NAP suggest that these peptides are neurotrophic and promote neurite outgrowth. These short peptides hold promise in future neuroprotective/ neurotrophic drug development. Clinical development of NAP is currently in progress by Allon Therapeutics, Inc.

Keywords: Vasoactive intestinal peptide (VIP), ciliary neurotrophic factor (CNTF), ADNF-9, neuroprotective, expression


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy