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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

COX-2 Inhibitors Celecoxib and Parecoxib: Valuable Options for Postoperative Pain Management

Author(s): Noor M. Gajraj

Volume 7 , Issue 3 , 2007

Page: [235 - 249] Pages: 15

DOI: 10.2174/156802607779941323

Price: $65

Abstract

COX-2 inhibitors are equally as efficacious as the non-selective NSAIDs for the treatment of postoperative pain, but have the advantages of a better gastrointestinal side-effect profile as well as a lack of antiplatelet effects. There have been recent concerns regarding the cardiovascular side effects of COX-2 inhibitors. Nonetheless, they remain a valuable option for postoperative pain management. The pharmacology of these agents and available studies are reviewed.

Keywords: Celecoxib, parecoxib, postoperative pain


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