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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

Author(s): Roy Asaf, Shany Blum, Rachel Miller-Lotan and Andrew P. Levy

Volume 4 , Issue 2 , 2007

Page: [160 - 162] Pages: 3

DOI: 10.2174/157018007779422479

Price: $65


Oxidative stress is responsible for myocardial injury occurring after ischemia and reperfusion (IR) and has been shown to be modulated by the Haptoglobin (Hp) genotype. In this manuscript we demonstrate that the antioxidant BXT -51072, a glutathione peroxidase synthetic mimic, provides protection against IR injury in a Hp genotype dependent fashion.

Keywords: Diabetes, Myocardial ischemia-reperfusion, Oxidative stress, BXT-51072

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