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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis

Author(s): Boris A.M. Pastorino, Christophe N. Peyrefitte, Marc Grandadam, Regine Lebrun, Danielle Moinier, Dominique Rolland, Hugues J. Tolou and Mael Bessaud

Volume 14 , Issue 1 , 2007

Page: [79 - 82] Pages: 4

DOI: 10.2174/092986607779117146

Price: $65

Abstract

We report herein the study of the cleavage fragments generated by autoproteolysis of the St. Louis encephalitis virus recombinant protease. The cleavage sites leading to truncated forms were identified by microsequencing, which revealed an unexpected altered specificity of the recombinant proteinase towards unusual sequences.

Keywords: Altered specificity, autoproteolysis, flavivirin, NS3, trypsin-like serine protease


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