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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Anti-Bacterial Drug Discovery Using Systems Biology

Author(s): K. D. Kumble

Volume 6 , Issue 11 , 2006

Page: [1275 - 1283] Pages: 9

DOI: 10.2174/138955706778742803

Price: $65


The pipeline for new antibacterials is bleak despite the fact that infectious diseases account for a quarter of all worldwide deaths due to disease. Bacteria are ideal organisms for a systems biology approach to understanding pathogenesis by combined use of genomic technologies and computer algorithms. This approach can be applied to identify control points in molecular networks, which could be targets for novel drugs.

Keywords: Genomics, systems biology, molecular networks, antibacterials, pathogens

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