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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Chemistry, Biological Properties and SAR Analysis of Quinoxalinones

Author(s): A. Carta, S. Piras, G. Loriga and G. Paglietti

Volume 6 , Issue 11 , 2006

Page: [1179 - 1200] Pages: 22

DOI: 10.2174/138955706778742713

Price: $65


Quinoxaline derivatives have received much attention in recent years owing to their both biological properties and pharmaceutical applications. In this review we focus the attention on quinoxalin-2(3)-ones and quinoxalin-2,3-diones. These derivatives are particularly interesting since some of them showed antimicrobial (against several bacteria, viruses, fungi, etc), or anticancer activities. Furthermore, others are reported to be potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities. In this article we also report SAR studies and the most important methods of synthesis of the quinoxalin-2(3)-(di)ones.

Keywords: Quinoxalin-2(3)-ones, quinoxalin-2,3-diones, AMPA antagonists, GlyN antagonists, antimicrobial activity, anticancer activity, Pgp antagonists, antiallergic activity, antithrombotic activity, SAR studies

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