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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8-HETE

Author(s): Pierre Renard, Daniel-Henri Caignard, Catherine Dacquet, Jean Boutin, Pascale Chomarat, Valerie Audinot-Bouchez, Rene Gree, Paul Mosset and Frederic Caijo

Volume 3 , Issue 2 , 2006

Page: [103 - 106] Pages: 4

DOI: 10.2174/157017806775224332

Price: $65


The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.

Keywords: 8-HETE, benzofuran, PPARs

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