Abstract
The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.
Keywords: 8-HETE, benzofuran, PPARs
Letters in Organic Chemistry
Title: Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8-HETE
Volume: 3 Issue: 2
Author(s): Pierre Renard, Daniel-Henri Caignard, Catherine Dacquet, Jean Boutin, Pascale Chomarat, Valerie Audinot-Bouchez, Rene Gree, Paul Mosset and Frederic Caijo
Affiliation:
Keywords: 8-HETE, benzofuran, PPARs
Abstract: The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.
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Cite this article as:
Renard Pierre, Caignard Daniel-Henri, Dacquet Catherine, Boutin Jean, Chomarat Pascale, Audinot-Bouchez Valerie, Gree Rene, Mosset Paul and Caijo Frederic, Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8-HETE, Letters in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157017806775224332
DOI https://dx.doi.org/10.2174/157017806775224332 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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