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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Inflammation and Antiangiogenesis in Cancer

Author(s): D. Ribatti, E. Crivellato and A. Vacca

Volume 19 , Issue 7 , 2012

Page: [955 - 960] Pages: 6

DOI: 10.2174/092986712799320655

Price: $65


The immune system regulates angiogenesis in cancer by means of pro- and anti-angiogenesis activities. In fact, both innate (macrophages, granulocytes, mast cells, dendritic cells, natural killer cells, and platelets) and adaptive (T and B lymphocytes) immune cells synthesize several pro- and anti-angiogenic mediators. Moreover, in pre-clinical models, a synergy has been observed between antiangiogenic molecules and immunotherapy. In this review article, we will focus on some angiogenenic and anti-angiogenic molecules properties of immune cells that may be utilized for a potential parmacological use as anti-angiogenic agents in cancer.

Keywords: Angiogenesis, anti-angiogenesis, adaptive immunity, inflammation, innate immunity, lymphocytes, macrophages, mast cells, neutrophils, platelets, tumor progression

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