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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

RNA Interference and Potential Applications

Author(s): Demin Zhou, Qiuchen S. He, Cuiying Wang, Jing Zhang and Flossie Wong-Staal

Volume 6 , Issue 9 , 2006

Page: [901 - 911] Pages: 11

DOI: 10.2174/156802606777303630

Price: $65

Abstract

RNA interference (RNAi) is the process of using specific sequences of double-stranded RNA (dsRNA) to knock down the expression level of sequence-homologous genes. Such ability of small interfering RNA (siRNA) in mammalian cells will undoubtedly revolutionize the study of functional genomics, the discovery of drug targets and even the treatment of human diseases. In this review we briefly describe the history of RNAi discovery, the RNAi mechanism and the general guideline for siRNA design as well as various methods for siRNA production and delivery. We also introduce the potential applications of siRNA, inducible siRNA and siRNA library in speeding up basic biomedical research and in acting as potential therapeutic agents for treatment of numerous human diseases.

Keywords: RNA interference, gene knockdown, siRNA, inducible siRNA, siRNA library, drug discovery, functional genomics


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