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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Relevance of Dopamine D2/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders

Author(s): S. Tanganelli, T. Antonelli, M. C. Tomasini, S. Beggiato, K. Fuxe and L. Ferraro

Volume 19 , Issue 3 , 2012

Page: [304 - 316] Pages: 13

DOI: 10.2174/092986712803414268

Price: $65

Abstract

The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS1/D2 receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration.

The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D2 or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.

Keywords: Neurotensin analogues, SR48692, NTS1 receptor, Antipsychotic drugs, Dopamine, Receptor heteromers, Microdialysis, Nucleus accumbens, Cerebral ischemia, Glutamate, Structure-activity relationship


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