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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Antioxidative Actions of Statins: Potential Mechanisms for Antiathersclerotic Effects

Author(s): Takanori Watanabe, Kenichi Yasunari and Munehoro Nakamura

Volume 6 , Issue 5 , 2006

Page: [505 - 508] Pages: 4

DOI: 10.2174/138955706776876249

Price: $65


Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.

Keywords: Statins, oxidative stress, atherosclerosis, carotid artery, leukocytes, flow cytemetory

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