Abstract
Skin cancer is the most common malignancy. Its pathogenesis is a multi-step, cumulative process which allows for potential intervention along the length of its spectrum. Cancer chemoprevention is a very promising approach to obtaining this goal. Unfortunately, its widespread application in clinic has been hampered by several problems, including systemic side effects especially if the medication requires prolonged use. For this reason, possible alternative measures have been investigated and are of great interest. The application of phytochemicals and other natural compounds is an appealing approach in that they are generally nontoxic, less costly and widely available. Topical application (e.g., transdermal systems, painting) of chemopreventives also serves as an alternative to systemic administration, and may limit side effects without sacrificing clinical advantages. The purpose of this paper is to provide an extensive investigation of the literature regarding current chemopreventative practices. This paper focuses discussions on the topical application of phytochemicals, by representing recent studies and findings. Based on recognition amongst the literature, five compounds are represented which include resveratrol, green tea, perillyl alcohol, ginger and inositol hexaphosphate. More compounds are also named with brief introduction, and further study is discussed.
Keywords: Skin cancer, chemoprevention, phytochemicals, topical application
Current Cancer Therapy Reviews
Title: Topical Chemoprevention of Skin Cancers with Phytochemicals
Volume: 7 Issue: 3
Author(s): Lining Feng, Mary C. Zoccoli and Zhi Wang
Affiliation:
Keywords: Skin cancer, chemoprevention, phytochemicals, topical application
Abstract: Skin cancer is the most common malignancy. Its pathogenesis is a multi-step, cumulative process which allows for potential intervention along the length of its spectrum. Cancer chemoprevention is a very promising approach to obtaining this goal. Unfortunately, its widespread application in clinic has been hampered by several problems, including systemic side effects especially if the medication requires prolonged use. For this reason, possible alternative measures have been investigated and are of great interest. The application of phytochemicals and other natural compounds is an appealing approach in that they are generally nontoxic, less costly and widely available. Topical application (e.g., transdermal systems, painting) of chemopreventives also serves as an alternative to systemic administration, and may limit side effects without sacrificing clinical advantages. The purpose of this paper is to provide an extensive investigation of the literature regarding current chemopreventative practices. This paper focuses discussions on the topical application of phytochemicals, by representing recent studies and findings. Based on recognition amongst the literature, five compounds are represented which include resveratrol, green tea, perillyl alcohol, ginger and inositol hexaphosphate. More compounds are also named with brief introduction, and further study is discussed.
Export Options
About this article
Cite this article as:
Feng Lining, C. Zoccoli Mary and Wang Zhi, Topical Chemoprevention of Skin Cancers with Phytochemicals, Current Cancer Therapy Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339411796234924
DOI https://dx.doi.org/10.2174/157339411796234924 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
New Ketonethiosemicarbazones for Melanogenesis Inhibition
Current Bioactive Compounds Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy
Current Pharmaceutical Biotechnology CD26/Dipeptidyl Peptidase IV as a Novel Therapeutic Target for Cancer and Immune Disorders
Mini-Reviews in Medicinal Chemistry Muscarinic Receptors as Targets for Metronomic Therapy in Breast Cancer
Current Pharmaceutical Design Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy
Current Pharmaceutical Design Enhancing the Site-Specific Targeting of Macromolecular Anticancer Drug Delivery Systems
Current Drug Targets The Quinoline Imidoselenocarbamate EI201 Blocks the AKT/mTOR Pathway and Targets Cancer Stem Cells Leading to a Strong Antitumor Activity
Current Medicinal Chemistry MEET THE GUEST EDITOR [Hot Topic: Modern Omics-Based Platform for High Throughput Screening for Novel Drug Targets (Part 2) (Guest Editor: Canhua Huang)]
Combinatorial Chemistry & High Throughput Screening Increasing Sensitivity to Radiotherapy and Chemotherapy by Using Novel Biological Agents that Alter the Tumor Microenvironment
Current Molecular Medicine Notch Inhibitors as a New Tool in the War on Cancer: A Pathway to Watch
Current Pharmaceutical Biotechnology The Clustered DNA Lesions – Types, Pathways of Repair and Relevance to Human Health
Current Medicinal Chemistry Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases in Carcinogenesis
Anti-Cancer Agents in Medicinal Chemistry Studies on the IC<sub>50</sub> of Trisubstituted Thiazoles as Cdc7 Kinase Inhibitors
Letters in Drug Design & Discovery Anticancer Potential of Aguerin B, a Sesquiterpene Lactone Isolated from <i>Centaurea behen</i> in Metastatic Breast Cancer Cells
Recent Patents on Anti-Cancer Drug Discovery Apoptotic Pathways in the Pathogenesis of Pemphigus: Targets for New Therapies
Current Pharmaceutical Biotechnology Contribution of Latin American Countries to Cancer Research and Patent Generation: Recent Patents
Recent Patents on Anti-Cancer Drug Discovery Curcumin: A Boon to Colonic Diseases
Current Drug Targets Deregulation of the Akt Pathway in Human Cancer
Current Cancer Drug Targets Pseudogene PTENP1 Suppresses Gastric Cancer Progression by Modulating PTEN
Anti-Cancer Agents in Medicinal Chemistry Anticancer Drug Sensitivity Testing, a Historical Review and Future Perspectives
Current Drug Therapy