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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis

Author(s): Somesh Baranwal and Suresh K. Alahari

Volume 12 , Issue 8 , 2011

Page: [1194 - 1201] Pages: 8

DOI: 10.2174/138945011795906534

Price: $65

Abstract

Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.

Keywords: Rho GTPase, ROCK, PAK, IQGAP, oncogenesis, metastasis, MDCK, ubiquitin-proteasome system, cancer


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