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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Rab GTPases, Membrane Trafficking and Diseases

Author(s): Guangpu Li

Volume 12 , Issue 8 , 2011

Page: [1188 - 1193] Pages: 6

DOI: 10.2174/138945011795906561

Price: $65


The Rab family of GTPases contains over 60 genes in the human genome and contributes to regulation of intracellular membrane trafficking along endocytic and exocytic pathways as well as specialized pathways in specific cell types. It has become increasingly clear that disruption of the intracellular membrane trafficking system at different stages can cause various diseases. In the past decade, altered expression levels and mutations of Rab GTPases have been associated with diseases such as cancer, Alzheimers disease, and various genetic disorders. This review discusses the specific Rab GTPases and their involvement in the diseases.

Keywords: Rab, GTPase, GTP-binding protein, cancer, genetic disorder, Alzheimer's disease, Carpenter syndrome, Griscelli syndrome, Hermansky-Pudlak Syndrome, mental retardation

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